Kırklarelİ, Türkei: Ausgrabungen in der neolithischen Siedlung Aşaǧı Pınar

The emergence of a new way of living in permanent settlements based on farming, conventionally addressed as the “Neolithic Revolution”, has been one of the most significant turning points in the history of civilization, with time leading to the emergence of more complex socio-economic models. The modalities of this new way of living, after having its initial evolutionary stages in certain parts of the Near East, from the beginning 7th Millennium on began dispersing to other region, thus becoming a global model. In this respect, the quest to find answers to questions when, how and why farming appeared in Europe has always been a matter of controversy. To find answers to these questions excavation at the Neolithic site of Aşağı Pınar, located in Eastern Thrace, the main contact zone of Anatolia with South-eastern Europe. Excavations at Aşağı Pınar have revealed an uninterrupted cultural sequence from c. 6200 to 4900 BC, from the time when the first farmers arrived in Thrace to its full adaptation to local environmental conditions. Aşağı Pınar became not only the key site for the chronology of the Karanovo I to IV sequence in Thrace but has made it possible to discern issues such as settlement organisation, social structuring and subsistence. Since 2010 two ditches could be excavated on a distance of 140 metres. Both ditches have no obvious functions like defense, water supply or working place. Recent observations not only in Aşağı Pınar but also in other Neolithic sites suggest to interpret ditch digging as a cultural phenomenon

An Overview of Various Additive Manufacturing Technologies and Materials for Electrochemical Energy Conversion Applications

© 2022 The Authors. Published by American Chemical Society.Additive manufacturing (AM) technologies have many advantages, such as design flexibility, minimal waste, manufacturing of very complex structures, cheaper production, and rapid prototyping. This technology is widely used in many fields, including health, energy, art, design, aircraft, and automotive sectors. In the manufacturing process of 3D printed products, it is possible to produce different objects with distinctive filament and powder materials using various production technologies. AM covers several 3D printing techniques such as fused deposition modeling (FDM), inkjet printing, selective laser melting (SLM), and stereolithography (SLA). The present review provides an extensive overview of the recent progress in 3D printing methods for electrochemical fields. A detailed review of polymeric and metallic 3D printing materials and their corresponding printing methods for electrodes is also presented. Finally, this paper comprehensively discusses the main benefits and the drawbacks of electrode production from AM methods for energy conversion systems

The role of microsatellite instability to predict clinical benefit from irinotecan-based regimens in metastatic colorectal cancer

The aim of our study was to assess the relationship between microsatellite instability (MSI) and the clinical outcome in metastatic colorectal cancer (CRC) patients treated with irinotecan-based regimens. We assessed best objective response, progression free survival (PFS) and overall survival (OAS) in relation to MSI analysis that was performed using BAT-25, BAT-26, D5S346, D2S123, D17S250 markers in normal and tumor DNA. The best objective response was significantly and negatively related with the D17S250 (an adjacent locus to p53) microsatellite marker (p=0.047). However, MSI score was not related with the best objective response (p=0.88). There was again no relationship between PFS, OAS and MSI score. In conclusion, this study allowed us to establish in a prospective study design that MSI status did not predict survival in metastatic colorectal cancer patients treated with irinotecan-based regimens